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Spore-based probiotics (Bacillus coagulans)
Gut health · IBS · Resilience
Tier 2 — Promising
What it is
Spore-forming probiotics survive stomach acid and shelf storage better than traditional strains, so they don't need refrigeration. Bacillus coagulans has the strongest evidence among spore-based probiotics, with multiple trials showing reduced IBS symptoms and improved gut barrier function. Generally well tolerated with no major side effects.
Efficacy
3/5
Safety
4/5
Research
3/5
Onset
3/5
Cost
3/5
Drug-int.
5/5
Dose
1–2 billion CFU/day; survives stomach acid without enteric coating
Time of day & tips
Can be taken with or without food — spore probiotics survive stomach acid and do not need to be taken before meals. No refrigeration required.
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