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SCORE
Silymarin phytosome (Siliphos)
Liver protection · NASH · Bioavailable milk thistle
Tier 2 — Promising
What it is
Milk thistle silymarin complexed with phosphatidylcholine, absorbing up to 10 times better than standard silymarin. Multiple Siliphos trials show significant improvements in liver enzymes and histology in NAFLD. The phospholipid complex also provides choline for liver fat metabolism. A 2025 review confirmed it outperforms standard silymarin.
Efficacy
3/5
Safety
4/5
Research
3/5
Onset
2/5
Cost
3/5
Drug-int.
4/5
Dose
120–240 mg/day silymarin as Siliphos phytosome; up to 10× better absorption than standard silymarin
Time of day & tips
Take with a meal containing fat — even the phytosome form benefits from dietary fat. Split into 2 daily doses. Allow 3–6 months for liver enzyme normalisation.
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