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Saccharomyces boulardii

Gut · C. diff · Traveller diarrhoea
Tier 1 — Strong Evidence

What it is

A unique probiotic yeast that antibiotics cannot kill, making it the only probiotic you can take during an antibiotic course without it being destroyed. Cochrane confirms it significantly reduces C. difficile recurrence and traveler's diarrhea. Very safe with an excellent track record. An essential travel companion for high-risk destinations.

Efficacy
4/5
Safety
5/5
Research
4/5
Onset
3/5
Cost
3/5
Drug-int.
4/5

Dose

250–500 mg (5–10 billion CFU) × 2 daily; safe during antibiotic courses

Time of day & tips

Take 1–2× daily with or without food, with cool or room-temperature water — not hot drinks. Unlike bacterial probiotics, this yeast survives antibiotics, so timing relative to antibiotics is not critical (still effective taken alongside).

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