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Riboflavin (Vitamin B2)

Migraine prevention · Energy metabolism

Tier 2 — Promising

What it is

One of the most affordable migraine prevention options available. A 2024 Cochrane update found 400 mg/day significantly reduces migraine frequency by roughly 2 days per month. Also essential for cellular energy metabolism. Water-soluble and very safe even at high doses — excess is simply excreted, turning urine bright yellow. Allow 3–6 months to assess the full benefit.

Efficacy

3/5

Safety

5/5

Research

3/5

Onset

1/5

Cost

5/5

Drug-int.

4/5

Dose

400 mg/day for migraine prevention; take with food; allow 3–6 months before assessing response

Time of day & tips

Take with food to improve tolerance. Urine will turn bright yellow — this is harmless. Consistent daily use is essential. Allow a full 3–6 months before judging effectiveness.

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