62
SCORE
Pycnogenol (pine bark, branded)
Circulation · Cognition · OA
Tier 2 — Promising
What it is
A proprietary French maritime pine bark extract standardised to 65–75% oligomeric procyanidins. A 2024 review of 28 trials found significant benefits for leg circulation, blood pressure, cognitive function, and knee OA pain. Over 160 clinical publications — the most studied pine bark extract. More expensive than generic OPC extracts but better evidenced.
Efficacy
3/5
Safety
4/5
Research
3/5
Onset
2/5
Cost
2/5
Drug-int.
4/5
Dose
100–200 mg/day standardised Pycnogenol; 200 mg studied for cognitive decline prevention
Time of day & tips
Take with a meal and water. Split into 2 doses for circulation and OA applications. Allow 4–8 weeks for chronic conditions. Avoid with immunosuppressants.
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