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Pueraria mirifica (Kwao Krua)

Menopause · Phytoestrogen · Women's health

Tier 3 — Trending

What it is

A Thai traditional herb containing miroestrol, the most potent known phytoestrogen. A 2024 systematic review of 6 trials found it significantly reduced hot flashes, vaginal dryness, and menopausal symptoms compared to placebo. Potent oestrogenic activity means it is contraindicated in hormone-sensitive cancers, endometriosis, and fibroids. Must not be combined with HRT without medical supervision.

Efficacy

3/5

Safety

3/5

Research

2/5

Onset

2/5

Cost

3/5

Drug-int.

2/5

Dose

25–50 mg/day standardised extract for menopausal symptoms; lower doses than most phytoestrogens due to high potency

Time of day & tips

Start at the lowest effective dose (25 mg/day). Absolutely contraindicated in hormone-sensitive cancers. Do not combine with HRT or oral contraceptives. Regular gynaecological check-ups recommended during use.

Sensitive populations: This supplement's evidence base touches pregnancy, pediatric, or other sensitive populations. Confirm any change with your healthcare provider before use.

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