54
SCORE
Pterostilbene
Resveratrol analogue · Cognition · Lipids
Tier 3 — Trending
What it is
A naturally methylated stilbene related to resveratrol, with substantially better oral bioavailability (~80% vs <1% for resveratrol). Small human trials show modest blood-pressure and lipid effects at 250 mg/day. Often paired with NR/NMN in branded longevity formulations. Generally well tolerated, though one trial noted a small LDL increase at higher doses — monitor lipids if used long-term.
Efficacy
2/5
Safety
4/5
Research
2/5
Onset
2/5
Cost
3/5
Drug-int.
4/5
Dose
50–250 mg/day; lower doses for general use, higher for trial-replicating regimens
Time of day & tips
Take with food; monitor lipid panel if used >250 mg/day or >3 months; commonly stacked with NMN/NR.
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