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SCORE
PQQ (Pyrroloquinoline quinone)
Mitochondria · Cognition · Energy
Tier 3 — Trending
What it is
Stimulates your cells to produce new energy-generating mitochondria, which may help combat age-related energy decline. Small trials show improved sleep quality and reduced fatigue. A 2024 trial found improved mental flexibility in older adults. Often combined with CoQ10 for synergistic effects. Generally safe, though long-term data is still limited.
Efficacy
2/5
Safety
4/5
Research
2/5
Onset
2/5
Cost
2/5
Drug-int.
4/5
Dose
10–20 mg/day with food; often combined with CoQ10
Time of day & tips
Take with a meal containing fat for best absorption. Morning or noon is best — may cause insomnia if taken in the evening.
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