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67
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Plant ceramides

Skin · Gut barrier · Hydration
Tier 2 — Promising

What it is

Ceramides are structural lipids essential for skin barrier integrity and gut epithelial function. Plant-derived ceramides (from wheat gliadin, konjac, or rice bran) can be incorporated into skin membranes after oral ingestion. A French RCT using wheat-derived ceramides showed significant improvements in skin hydration, smoothness, and elasticity within 3 months. Emerging gut barrier data is also encouraging. A novel but biologically plausible supplement category with an excellent safety profile.

Efficacy
3/5
Safety
5/5
Research
2/5
Onset
3/5
Cost
3/5
Drug-int.
4/5

Dose

30–200 mg/day wheat gliadin ceramide complex with a fat-containing meal

Time of day & tips

Consistent daily intake for at least 4–8 weeks needed; wheat-derived forms are contraindicated in coeliac disease; take with fat for best absorption

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