64
SCORE
Phosphatidylserine (plant-derived)
Cognition · Cortisol · Memory
Tier 2 — Promising
What it is
FDA allows a qualified health claim for phosphatidylserine reducing cognitive decline risk. The plant-derived form replaced bovine cortex used in older trials. A 2024 review confirmed it significantly reduces cortisol after stress and modestly improves memory in older adults. Sunflower-derived preferred for soy-sensitive individuals.
Efficacy
3/5
Safety
4/5
Research
3/5
Onset
2/5
Cost
3/5
Drug-int.
4/5
Dose
300 mg/day in 3 doses (100 mg × 3) with meals; sunflower-derived form preferred for soy allergy
Time of day & tips
Take with meals split across 3 doses through the day. Takes 6–8 weeks for memory benefits. Safe for long-term use. Sunflower-derived preferred for soy-sensitive individuals.
Compare or learn more
Compare with another supplement →
Browse by symptom →
Open the full interactive view →