53
SCORE
Phloretin
Antioxidant · Skin · Insulin sensitivity
Tier 3 — Trending
What it is
A dihydrochalcone polyphenol abundant in apple peel and leaves. Phloretin inhibits glucose transporters GLUT1 and GLUT2, moderating post-meal glucose flux. In vitro and animal studies show anti-inflammatory, antioxidant, and potential SIRT1-activating activity. Widely used in topical skincare for antioxidant and melanogenesis-inhibiting properties. Very limited human trial data as an oral supplement. Mechanistically interesting but currently preclinical for most claimed benefits.
Efficacy
2/5
Safety
5/5
Research
1/5
Onset
2/5
Cost
3/5
Drug-int.
3/5
Dose
50–200 mg/day with food
Time of day & tips
Emerging evidence only; whole apple polyphenol extracts may provide a more complete flavonoid matrix than isolated phloretin
Compare or learn more
Compare with another supplement →
Browse by symptom →
Open the full interactive view →