Pantethine
What it is
The active form of vitamin B5 that your body uses to make coenzyme A. Multiple trials show 600 to 900 mg per day significantly lowers total cholesterol by about 11 percent and triglycerides by about 30 percent. Works through a different mechanism than statins, so it can be used alongside them. Generally well tolerated with mild digestive side effects in some people. Takes 4 to 8 months for full lipid-lowering effect.
Dose
300 mg × 2–3 daily with meals; allow 4–8 months for full cholesterol-lowering effect
Time of day & tips
Take with meals — 2–3 times daily with food. Takes 4–8 months for full effect. Can be combined with omega-3s or plant sterols for additional cholesterol support.
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