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Pancreatin (porcine digestive enzymes)

Pancreatic insufficiency · Digestion · Fat absorption

Tier 2 — Promising

What it is

Prescription-strength digestive enzymes from porcine pancreas containing lipase, amylase, and protease. FDA-approved for exocrine pancreatic insufficiency. Also used off-label for general digestive support. Significantly more potent than plant-based enzyme blends. Enteric coating is essential to survive stomach acid. Over-the-counter versions are available at lower potencies.

Efficacy

4/5

Safety

4/5

Research

3/5

Onset

4/5

Cost

3/5

Drug-int.

4/5

Dose

Over-the-counter: 1–2 capsules (10,000–25,000 USP lipase units) with each meal. EPI/cystic fibrosis prescription: 25,000–75,000 USP lipase units with meals (10,000–25,000 with snacks). Enteric-coated; do not crush.

Time of day & tips

Take with every meal and snack. Swallow whole — do not crush enteric-coated capsules. Avoid taking with antacids, which can dissolve the protective coating.

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