Palmitoylethanolamide (PEA)
What it is
A natural pain-relieving compound your body already makes in small amounts. A 2024 review of 16 trials found PEA significantly reduces neuropathic and arthritis pain. Excellent safety profile — no known drug interactions reported in any trial. Must use ultramicronised (um-PEA) or co-micronised forms; standard PEA absorbs poorly and may not work. Allow 4–8 weeks for full effect.
Dose
300–600 mg/day ultramicronised or co-micronised form (um-PEA or co-PEA); standard form poorly absorbed
Time of day & tips
Take with a light meal or snack to improve absorption. Split into 2 doses (morning and evening). No known drug interactions. Allow 4–8 weeks for full pain-relief effect.
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