72
SCORE
Palmitoylethanolamide co-micronised (m-PEA)
Chronic pain · Fibromyalgia · Neuropathic pain
Tier 2 — Promising
What it is
Co-micronised PEA with luteolin activates natural pain-resolving pathways without receptor desensitisation. A 2024 review of 16 trials found it significantly reduces neuropathic pain, sciatica, and fibromyalgia. Entirely free of drug interactions. The co-micronised form is essential — standard PEA absorbs poorly.
Efficacy
3/5
Safety
5/5
Research
3/5
Onset
3/5
Cost
3/5
Drug-int.
5/5
Dose
300–600 mg/day co-micronised PEA with luteolin (Normast or equivalent); allow 6–8 weeks for effect
Time of day & tips
Take with a light meal or snack. Split into morning and evening doses. No drug interactions. Allow 8 weeks before judging — pain relief builds gradually. Standard PEA does not work.
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