Oleoylethanolamide (OEA)
What it is
A monounsaturated fatty acid ethanolamide produced endogenously in the small intestine during fat ingestion, acting at PPAR-alpha to signal satiety. Oral supplementation in humans modestly reduces food intake, waist circumference, and LDL. Structurally related to the endocannabinoid anandamide but does not activate cannabinoid receptors — instead it suppresses appetite via PPAR-alpha. A complementary mechanism to GLP-1 agonists and fibre. Safety profile in short-term trials is good but long-term data are limited.
Dose
100–300 mg before meals, 1–3 times daily
Time of day & tips
Take 30 min before meals for appetite effect; evidence is modest but mechanism is well-characterised; synergistic with fibre and protein for satiety
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