Nicotinic acid (Niacin, flush form)
What it is
The flushing form of vitamin B3, distinct from niacinamide. At pharmacological doses (1.5-3 g/day) nicotinic acid is the single most effective agent for raising HDL (+20-30%) and reducing Lp(a) (-25-35%) — uniquely among lipid drugs. Also lowers LDL and triglycerides. The famous flush results from prostaglandin D2 release and is harmless but uncomfortable. However AIM-HIGH and HPS2-THRIVE showed no cardiovascular benefit added to statins, and adverse effects (hyperglycaemia, hepatotoxicity at sustained-release doses) are meaningful.
Dose
500 mg–3 g/day, titrated up slowly; use immediate-release, not sustained-release
Time of day & tips
Take with food and 325 mg aspirin 30 min prior to reduce flush; avoid sustained-release (hepatotoxicity risk); monitor LFTs and glucose; physician supervision above 1 g
Compare or learn more
Compare with another supplement →
Browse by symptom →
Open the full interactive view →