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SCORE
Nicotinamide riboside (NR)
NAD+ · Aging · Cellular energy
Tier 3 — Trending
What it is
A precursor to NAD+ that successfully raises blood NAD+ levels in humans. Multiple trials confirm NR supplementation at 300 to 1,000 mg per day significantly increases NAD+ within 2 weeks. However, like NMN, no meaningful clinical health improvements have been demonstrated yet despite raised NAD+. The gap between biomarker changes and actual health benefits remains the key unanswered question.
Efficacy
3/5
Safety
4/5
Research
2/5
Onset
2/5
Cost
1/5
Drug-int.
4/5
Dose
300–1,000 mg/day; successfully raises NAD+ but no clinical health benefits demonstrated yet
Time of day & tips
Take in the morning with or without food. Avoid late in the day as it may affect sleep. No known food interactions at standard doses.
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