62
SCORE
N-Acetyl glucosamine
Gut barrier · IBD · Joint
Tier 2 — Promising
What it is
A building block of the gut mucus layer that protects the intestinal lining. Different from regular glucosamine used for joints. Small trials in IBD showed improved gut barrier integrity. Also plays a role in joint cartilage maintenance. Generally very safe with no serious side effects reported. Larger RCTs are still needed.
Efficacy
2/5
Safety
5/5
Research
2/5
Onset
3/5
Cost
3/5
Drug-int.
5/5
Dose
500–1,500 mg/day; different from glucosamine sulfate used for joint pain
Time of day & tips
Take with food. Can be taken at any time of day. Safe to combine with other gut-support supplements.
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