MitoQ
What it is
A mitochondria-targeted ubiquinone conjugated to a lipophilic triphenylphosphonium cation, causing it to accumulate 1000-fold inside mitochondria compared with standard CoQ10. Multiple human RCTs show improvements in vascular endothelial function in older adults, reduced fatigue in relapsing MS, and reduced ICU-acquired weakness markers. The targeted delivery matters more than the total antioxidant capacity — unlike conventional antioxidants, MitoQ acts precisely where ROS are generated.
Dose
10–20 mg/day on an empty stomach
Time of day & tips
Take first thing in the morning 30 minutes before food; not a CoQ10 replacement for heart failure (insufficient systemic coverage); avoid if on complex mitochondrial therapies without specialist advice
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