56
SCORE
Methyl B12 + Methylfolate combo
MTHFR · Methylation · Energy
Tier 3 — Trending
What it is
Marketed to people with the MTHFR gene variant, which about 40% of the population carries. NIH notes most carriers have perfectly normal folate metabolism and do not need special supplements. Only clinically needed when blood tests actually show low folate, low B12, or elevated homocysteine levels. Safe but usually unnecessary for healthy people.
Efficacy
2/5
Safety
4/5
Research
2/5
Onset
3/5
Cost
3/5
Drug-int.
4/5
Dose
1,000 mcg methyl-B12 + 400 mcg 5-MTHF/day; test homocysteine and serum levels first
Time of day & tips
Take in the morning with water. May cause vivid dreams or restlessness if taken at night. Can take with or without food.
Compare or learn more
Compare with another supplement →
Browse by symptom →
Open the full interactive view →