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Magnesium bisglycinate

Sleep · Anxiety · Bioavailability
Tier 1 — Strong Evidence

What it is

The glycinate-chelated form of magnesium that absorbs significantly better than oxide and has minimal laxative effect. Multiple trials confirm it improves sleep quality and reduces anxiety by activating GABA receptors. Ideal for people who get diarrhea from citrate or other forms. A 2024 review found it the best-tolerated form for daily use. Widely recommended by sleep and anxiety specialists.

Efficacy
4/5
Safety
5/5
Research
3/5
Onset
3/5
Cost
3/5
Drug-int.
5/5

Dose

200–400 mg elemental magnesium as bisglycinate before bed; best tolerated form for sleep and anxiety

Time of day & tips

Take in the evening, 30–60 min before bed. No laxative effect at normal doses. Take with food if stomach-sensitive. Space 2 hours from antibiotics and iron.

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