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Magnafolate (calcium L-methylfolate)
Active folate · MTHFR · Methylation
Tier 3 — Trending
What it is
A patented stable crystalline form of L-5-methyltetrahydrofolate, distinct from Quatrefolic (a glucosamine salt of the same active folate). Both deliver pre-converted active folate that bypasses the MTHFR enzyme step. Especially relevant for the ~30% of the population with reduced-activity MTHFR variants. Equivalent in effect to Quatrefolic; choice between the two is largely about supply and price.
Efficacy
3/5
Safety
5/5
Research
3/5
Onset
2/5
Cost
3/5
Drug-int.
5/5
Dose
400–1,000 mcg L-methylfolate daily
Time of day & tips
Take with food; preferred over folic acid in MTHFR variants; over-methylation symptoms (irritability, insomnia) at high doses can sometimes be relieved by adding niacinamide.
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