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Luteolin
Cognition · Neuroprotection · Inflammation
Tier 3 — Trending
What it is
A flavone found in parsley, celery, and chamomile with potent anti-neuroinflammatory properties. Luteolin inhibits microglial activation, reduces pro-inflammatory cytokines (TNF-α, IL-6), and stabilises mast cells — making it particularly relevant for brain fog, mast cell activation syndrome, and neurological conditions. Preliminary human trials show benefit in autism spectrum disorder-related irritability and cognitive performance. Crosses the blood-brain barrier modestly.
Efficacy
3/5
Safety
4/5
Research
2/5
Onset
2/5
Cost
3/5
Drug-int.
3/5
Dose
100–300 mg/day with a fat-containing meal
Time of day & tips
Use a bioavailable form; synergistic with quercetin; take with fat for absorption; avoid very high doses long-term
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