Lactobacillus helveticus/B. longum R0052/R0175
What it is
A specific probiotic combination (marketed as Cerebiome) with clinical evidence for the gut-brain axis. The landmark Messaoudi 2011 RCT (Br J Nutr) found this combination significantly reduced cortisol and psychological distress scores compared to placebo. Later trials (Kazemi 2019, Chahwan 2019) tested similar combinations in depression with more mixed results. One of the few probiotics with direct — if still modest — evidence for mood outcomes in adults.
Dose
3 billion CFU/day of the R0052/R0175 combination; specific strains matter — generic alternatives are unproven
Time of day & tips
Take daily with or without food. Allow 4 weeks for mood benefits to become noticeable. Strain specificity matters — generic L. helveticus and B. longum are not interchangeable with these specific strains.
Compare or learn more
Compare with another supplement →
Browse by symptom →
Open the full interactive view →