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L-Ornithine

Sleep · Ammonia detox · Exercise recovery
Tier 3 — Trending

What it is

An amino acid involved in the urea cycle that helps your body clear ammonia, a metabolic waste product. Small trials show it improves sleep quality when taken before bed and reduces fatigue during prolonged exercise. Often combined with L-arginine for growth hormone release, though the GH effect is modest and short-lived. Very safe with no serious side effects reported in clinical studies.

Efficacy
2/5
Safety
4/5
Research
2/5
Onset
3/5
Cost
3/5
Drug-int.
5/5

Dose

400–800 mg before bed for sleep or 2–6 g before exercise for recovery

Time of day & tips

For sleep, take 400–800 mg on an empty stomach 30 min before bed. For exercise, take 1–2 hours before training. Best with water, not a high-protein meal.

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