54
SCORE
L-Histidine
Joint · Anaemia · Immune modulation
Tier 3 — Trending
What it is
A semi-essential amino acid needed for histamine production, haemoglobin synthesis, and antioxidant defence via carnosine. A few trials show it improves fatigue in CKD and reduces joint inflammation in rheumatoid arthritis. Deficiency is rare with adequate dietary protein. Very safe at standard doses.
Efficacy
2/5
Safety
4/5
Research
2/5
Onset
2/5
Cost
3/5
Drug-int.
4/5
Dose
1–4 g/day; most useful for CKD fatigue and RA; deficiency rare with adequate dietary protein
Time of day & tips
Take with water at any time of day. Can be taken with or without food. Rarely needed if you eat adequate protein from meat, fish, eggs, or dairy.
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