L-Glutamine (post-infectious IBS)
What it is
The primary fuel for intestinal epithelial cells and lymphocytes. A 2019 Gut trial (Zhou et al.) found 15 g/day for 8 weeks significantly reduced IBS-D symptoms and restored gut barrier function in patients with diarrhea-predominant post-infectious IBS. Effects in other IBS subtypes are not established. Healthy people with an intact mucosa already synthesise large amounts of glutamine in skeletal muscle, and additional supplementation adds little — the indication is narrow and condition-specific.
Dose
15 g/day in 3 divided doses for post-infectious IBS-D; minimal benefit in general healthy population
Time of day & tips
Dissolve in water or juice. Take 30 min before or between meals for gut-barrier focus. Can be taken with food. No significant drug interactions at standard doses.
Compare or learn more
Compare with another supplement →
Browse by symptom →
Open the full interactive view →