Kaempferol
What it is
A flavonol found in kale, broccoli, capers, apples, and green tea that activates autophagy (cellular cleanup impaired in aging), inhibits NF-κB, STAT3, and PI3K signalling, and exhibits senolytic activity (selectively killing aged senescent cells) in cell culture. Epidemiological studies consistently associate higher dietary kaempferol with reduced colorectal, pancreatic, and lung cancer risk. Human clinical data for supplements is extremely limited — a 2023 pilot trial found kaempferol modestly improved insulin sensitivity markers. Most evidence is from in vitro, animal, and epidemiological studies. Dietary sources (kale, capers) remain the most evidence-backed delivery method.
Dose
25–100 mg/day standardised kaempferol supplement; prioritise dietary sources over supplements
Time of day & tips
Prioritise dietary sources — kale (30 mg/100g), capers (234 mg/100g), broccoli, dill, and spinach are among the richest sources. Supplement if dietary intake is consistently insufficient. May mildly inhibit CYP3A4 at high supplemental doses — space from medications metabolised by this enzyme. Combine with quercetin and fisetin for a broader flavonoid longevity stack.
Cycling
No established cycling protocol for supplements. Consistent dietary kaempferol from whole foods is the safest and most evidence-based approach.
Compare or learn more
Compare with another supplement →
Browse by symptom →
Open the full interactive view →