62
SCORE
K2 + D3 combo
Bone · Cardiovascular · Calcium regulation
Tier 2 — Promising
What it is
Vitamin D3 increases calcium absorption while K2 (MK-7) directs that calcium into bones and away from arteries via carboxylation of osteocalcin and MGP. The combination is biologically sound and widely used, but few RCTs have tested the specific combination versus each vitamin alone. Both are very safe and individually well-supported.
Efficacy
2/5
Safety
5/5
Research
2/5
Onset
3/5
Cost
4/5
Drug-int.
4/5
Dose
1,000–2,000 IU D3 + 100–200 mcg K2 (MK-7) daily; combination logic is sound but not directly validated
Time of day & tips
Take with a fatty meal — both are fat-soluble vitamins that need dietary fat to absorb properly. Once daily with your largest meal is ideal.
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