SCORE

Japanese knotweed (Polygonum cuspidatum)

Resveratrol source · Lyme adjunct

Tier 3 — Trending

What it is

An invasive perennial that is the commercial source of most nutraceutical resveratrol (typically 50-98% trans-resveratrol extracts are derived from it). Whole-root extracts additionally provide emodin, polydatin (resveratrol's glucoside), and anthraquinones with their own bioactivity. Popular in the Buhner Lyme protocol as an anti-inflammatory and blood-brain-barrier support. Emodin content may cause laxative effects at high doses. A natural alternative to isolated resveratrol with broader constituent profile.

Efficacy

2/5

Safety

3/5

Research

2/5

Onset

3/5

Cost

4/5

Drug-int.

4/5

Dose

400–2000 mg whole-root extract (standardised to 8–50% resveratrol) daily

Time of day & tips

Prefer root extract over isolated resveratrol for broader action; start low to assess emodin-related GI effects; avoid in pregnancy and with strong anticoagulants

Sensitive populations: This supplement's evidence base touches pregnancy, pediatric, or other sensitive populations. Confirm any change with your healthcare provider before use.

Compare or learn more

Compare with another supplement →
Browse by symptom →
Open the full interactive view →

Educational reference, not medical advice. About · Methodology · Privacy · Terms