Inositol hexanicotinate
What it is
A slow-release niacin form where six niacin molecules are esterified to inositol, marketed as flush-free niacin. Slower hydrolysis yields lower peak plasma niacin than immediate-release forms — explaining both reduced flushing and weaker lipid effects observed in controlled trials. Modest triglyceride reductions and small HDL increases have been documented. Appropriate for individuals genuinely intolerant of niacin flushing who still want some lipid support, but should not substitute for pharmacological niacin when strong effects are needed.
Dose
1,000–1,500 mg/day in divided doses with meals
Time of day & tips
Do not expect the same lipid effects as crystalline niacin; monitor liver enzymes with chronic use above 1 g/day; significantly weaker than standard niacin
Compare or learn more
Compare with another supplement →
Browse by symptom →
Open the full interactive view →