60
SCORE
Hyaluronic acid + Chondroitin stack
Joint · Skin · Connective tissue
Tier 2 — Promising
What it is
A combination of oral hyaluronic acid and chondroitin sulfate to support joint lubrication and cartilage integrity. A 2024 trial found the combination modestly reduced knee stiffness and improved mobility after 3 months. Evidence for each component individually is modest. Very safe with no known drug interactions.
Efficacy
2/5
Safety
5/5
Research
2/5
Onset
2/5
Cost
3/5
Drug-int.
5/5
Dose
80–200 mg/day low-MW hyaluronic acid + 400–800 mg/day chondroitin sulfate; allow 3 months
Time of day & tips
Take with food. Timing is flexible. Allow a full 3 months before evaluating benefits. Very well tolerated — no need to take a break or cycle off.
Compare or learn more
Compare with another supplement →
Browse by symptom →
Open the full interactive view →