Honokiol (magnolia bark isolate)
What it is
A bioactive lignan isolated from Magnolia officinalis bark with potent antioxidant activity (1,000× more potent than vitamin E in lipid systems) and multitarget neurological effects: positive allosteric modulation of GABA-A receptors (anxiolytic without tolerance), NMDA receptor modulation (neuroprotective), and NF-κB inhibition (anti-inflammatory). Small human studies and extensive preclinical models show anxiety reduction without the tolerance development that limits benzodiazepines. Emerging evidence for neuroprotection against Alzheimer's pathology (reduces beta-amyloid and tau aggregation in rodents). Available in magnolia bark extract or isolated honokiol standardised supplements.
Dose
50–200 mg/day standardised honokiol; evening dosing for anxiety and sleep applications; start at 50 mg and titrate up
Time of day & tips
Take in the evening or 1–2 hours before bed for anxiety and sleep. May potentiate sedatives, benzodiazepines, and alcohol — use caution combining with CNS depressants. Start at the lowest effective dose. Can also be used during the day for anti-inflammatory applications at lower doses.
Cycling
No established cycling protocol. Unlike benzodiazepines, tolerance has not been demonstrated in preclinical studies. Regular use appears safe in available animal and small human studies.
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