69
SCORE
Hesperidin methyl chalcone
Leg swelling · Circulation · Venous tone
Tier 2 — Promising
What it is
A modified form of hesperidin with improved water solubility and better absorption than standard hesperidin. Multiple European trials show it significantly reduces leg swelling, heaviness, and pain from venous insufficiency and varicose veins within 6 weeks. Often combined with diosmin in French vein-health formulas. Very safe with no known drug interactions at tested doses.
Efficacy
3/5
Safety
5/5
Research
2/5
Onset
3/5
Cost
3/5
Drug-int.
5/5
Dose
500 mg/day hesperidin methyl chalcone alone or as part of diosmin-HMC combination
Time of day & tips
Take with food. Consistent daily use for at least 6 weeks before assessing results. Combining with leg elevation and regular walking enhances circulation benefits.
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