Green-lipped mussel (Perna canaliculus)
What it is
A New Zealand shellfish (Perna canaliculus) providing a unique lipid fraction including eicosatetraenoic acid (ETA), omega-3s, and furan fatty acids with anti-inflammatory activity distinct from standard fish oil. Meta-analyses show clinically meaningful reductions in osteoarthritis pain and stiffness, with effect sizes comparable to NSAIDs but better tolerance. Stabilised lipid extract (Lyprinol/Pernaton) has the strongest evidence; freeze-dried powders are less reliable. Avoid with shellfish allergy.
Dose
200–400 mg standardised lipid extract or 1000–3000 mg freeze-dried powder daily
Time of day & tips
Lipid extract (Lyprinol) is more potent than powder; take with food; allow 4-8 weeks for joint benefits; contraindicated in shellfish allergy
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