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SCORE
Grape seed extract (OPC)
Antioxidant · Circulation · Blood pressure
Tier 3 — Trending
What it is
A plant antioxidant that may modestly lower blood pressure. A 2024 review of 15 trials found a small but significant blood pressure reduction of about 3.2 mmHg. Its antioxidants improve blood vessel function, but overall heart health evidence is weaker than expected given the strong lab data. Generally well tolerated with no major side effects.
Efficacy
2/5
Safety
4/5
Research
2/5
Onset
2/5
Cost
3/5
Drug-int.
4/5
Dose
150–300 mg/day standardised extract (≥95% OPCs)
Time of day & tips
Take with water, with or without food. Morning or noon is a good time. Avoid taking with blood thinners or anticoagulants without medical guidance.
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