GHK-Cu (copper tripeptide, topical)
What it is
A naturally occurring copper-binding tripeptide present in human plasma, with declining concentrations after age 50. Topical formulations have moderate evidence for wrinkle reduction, skin elasticity, and post-procedure recovery; smaller evidence for hair follicle health. Oral or injected use is not recommended for self-administration — copper toxicity risk and the same regulatory ambiguity as other peptides apply. Cosmetic-grade topical products are widely available.
Dose
Topical only: 0.1–2% serum or cream, applied 1–2× daily
Time of day & tips
Topical use is the only well-supported route; do not inject; do not combine in the same session with strong vitamin C topicals (the copper can oxidise ascorbate); patch-test for sensitivity.
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