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Gamma-oryzanol (rice bran)

Lipids · Menopause · Antioxidant

Tier 3 — Trending

What it is

A mixture of ferulic acid esters of triterpene alcohols and phytosterols from rice bran oil. Used extensively in Japan since the 1960s for hyperlipidaemia, menopausal symptoms, and mild anxiety. Human RCTs support modest LDL lowering (~10%), reduction of menopausal vasomotor symptoms, and mild anxiolytic effect. Safety record is excellent — gamma-oryzanol was Japan's prescription drug for menopause for decades. Often under-recognised in Western supplement markets.

Efficacy

2/5

Safety

4/5

Research

2/5

Onset

3/5

Cost

3/5

Drug-int.

4/5

Dose

100–300 mg gamma-oryzanol 3 times daily

Time of day & tips

Take with meals; lipid and menopausal effects take 8-12 weeks; well-tolerated; distinct from rice bran oil (which contains only small amounts of gamma-oryzanol)

Sensitive populations: This supplement's evidence base touches pregnancy, pediatric, or other sensitive populations. Confirm any change with your healthcare provider before use.

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