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EGCG concentrate (decaffeinated green-tea catechin)

Antioxidant · Metabolic · Hepatotoxicity risk at high dose

Tier 2 — Promising

What it is

Epigallocatechin-3-gallate is the principal catechin in green tea. Standardised decaffeinated EGCG extracts have moderate evidence for modest weight and lipid endpoints, and a smaller body of evidence for cancer adjunct use. Crucially, high-dose concentrated EGCG (>800 mg/day on empty stomach) has been linked to hepatotoxicity case reports — EFSA flagged this in 2018. Stay at or below the safety guidance dose, take with food, and discontinue if any liver-related symptoms develop.

Efficacy

3/5

Safety

3/5

Research

4/5

Onset

2/5

Cost

3/5

Drug-int.

3/5

Dose

200–400 mg/day with food; do not exceed 800 mg/day per EFSA guidance

Time of day & tips

Always take with food (NOT empty stomach); avoid in chronic liver disease and during pregnancy; monitor LFTs at higher doses or longer-term use; discontinue on any symptom of fatigue or RUQ pain.

Sensitive populations: This supplement's evidence base touches pregnancy, pediatric, or other sensitive populations. Confirm any change with your healthcare provider before use.

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