DMG (Dimethylglycine)
What it is
A tertiary amine derivative of glycine marketed for athletic performance, immune support, and autism. Once known as 'vitamin B15' or 'pangamic acid' (a misnomer — it is neither a vitamin nor pangamic acid). Serves as a methyl donor and is an intermediate in the conversion of betaine to glycine. Small human trials show equivocal results for performance; autism studies are underpowered. Broadly very safe and well-tolerated. Best viewed as a mild methylation adjunct with modest standalone evidence.
Dose
125–500 mg 1–3 times daily
Time of day & tips
Take between meals; effects (if any) build over 2-4 weeks; avoid confusing with TMG (trimethylglycine/betaine) which is better evidenced; discontinue if no effect at 6 weeks
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