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DLPA (DL-Phenylalanine)

Mood · Pain · Catecholamines

Tier 3 — Trending

What it is

A racemic mixture of L-phenylalanine (a normal amino acid, precursor to tyrosine and catecholamines) and D-phenylalanine (a non-proteinogenic enantiomer that inhibits enkephalinase, potentially extending endogenous opioid action). Small older trials suggested benefit for mild depression and chronic pain, but modern replication is thin. Mechanism for pain is plausible (enkephalinase inhibition) but evidence base is limited. Avoid with MAOIs and in phenylketonuria. Short-term use for pain/mood trial is reasonable.

Efficacy

2/5

Safety

4/5

Research

2/5

Onset

3/5

Cost

4/5

Drug-int.

3/5

Dose

500–1500 mg before breakfast, with a second dose before lunch if well tolerated

Time of day & tips

Take on empty stomach 30 min before food; avoid with MAOIs, in PKU, and in late pregnancy; discontinue if no effect at 4-6 weeks; may cause headache in sensitive individuals

Sensitive populations: This supplement's evidence base touches pregnancy, pediatric, or other sensitive populations. Confirm any change with your healthcare provider before use.

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