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SCORE
Dihydroberberine (DHB)
Blood sugar · Bioavailability · Metabolic
Tier 3 — Trending
What it is
A reduced form of berberine absorbing 5 times better than standard berberine, with similar glucose-lowering at a lower dose and fewer GI side effects. A 2024 trial found 100 mg DHB equivalent to 500 mg standard berberine. Still emerging with limited long-term data. Drug interactions mirror berberine.
Efficacy
3/5
Safety
3/5
Research
2/5
Onset
2/5
Cost
2/5
Drug-int.
3/5
Dose
100–300 mg/day DHB; equivalent to 500–1,500 mg standard berberine at lower dose with less GI upset
Time of day & tips
Take with meals to minimise stomach discomfort. Same drug interaction cautions as regular berberine — avoid with metformin without guidance. Monitor blood sugar closely.
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