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DGL Licorice (deglycyrrhizinated)

GERD · Ulcer · Gut lining

Tier 2 — Promising

What it is

Regular licorice causes dangerous blood pressure spikes and potassium depletion, but the DGL form has the toxic glycyrrhizin removed. Multiple trials show DGL helps heal stomach ulcers and relieve acid reflux symptoms by stimulating mucus production that protects the gut lining. Chewable tablets taken before meals work best. Very safe with none of the cardiovascular risks of regular licorice. A good option for people wanting to reduce antacid use.

Efficacy

3/5

Safety

5/5

Research

3/5

Onset

3/5

Cost

4/5

Drug-int.

5/5

Dose

380–760 mg chewable DGL 20 min before meals; safe long-term (glycyrrhizin removed)

Time of day & tips

Chew tablets 20 min before meals for best effect on gut lining. Swallowing whole reduces effectiveness. Safe for long-term use at recommended doses.

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