64
SCORE
Devil's claw (Harpagophytum procumbens)
Joint pain · Back pain · Inflammation
Tier 2 — Promising
What it is
A South African herb with strong evidence for lower back pain and osteoarthritis. ESCOP and multiple Cochrane-quality reviews confirm significant pain reduction at doses providing 50 to 100 mg harpagoside daily. Works through anti-inflammatory pathways similar to NSAIDs. May cause digestive upset in some people. Avoid with blood thinners and stomach ulcers.
Efficacy
3/5
Safety
4/5
Research
3/5
Onset
2/5
Cost
3/5
Drug-int.
4/5
Dose
600–1,200 mg/day extract providing 50–100 mg harpagoside; avoid with anticoagulants
Time of day & tips
Take with food to reduce stomach upset. Avoid with blood thinners or if you have a stomach ulcer. Space away from anti-inflammatory drugs.
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