Delta-tocotrienol
What it is
A tocotrienol isomer (vitamin E family) derived from annatto or palm oil with distinct biological activity from tocopherols. Delta- and gamma-tocotrienols inhibit HMG-CoA reductase post-transcriptionally, reducing cholesterol synthesis — RCTs in hyperlipidaemia show 10–15% LDL reductions. Also shows promise in reducing inflammatory markers in NAFLD and in preclinical cancer adjunct work. Tocopherol-free (annatto-derived) preparations are preferred; alpha-tocopherol interferes with tocotrienol uptake.
Dose
125–300 mg delta/gamma tocotrienols (annatto-sourced) daily
Time of day & tips
Take without alpha-tocopherol (separate by 6+ hours or choose alpha-free formulas); with evening meal; monitor lipids at 8-12 weeks
Compare or learn more
Compare with another supplement →
Browse by symptom →
Open the full interactive view →