D-Glucuronolactone
What it is
A naturally occurring compound derived from glucose that participates in glucuronic acid conjugation — a key pathway in liver detoxification. Widely used in energy drinks at 600–2,400 mg per serving. At standalone therapeutic doses, limited data suggests liver-supportive and modest alertness-promoting effects, likely via synergy with taurine and caffeine rather than direct standalone action. Safety data as an isolated high-dose supplement is limited.
Dose
400–1,200 mg/day, often combined with caffeine or taurine
Time of day & tips
Most evidence comes from energy drink contexts alongside caffeine; standalone data is sparse; don't exceed 1,200 mg as isolated supplement
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