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Curcumin (bioavailable form)

Inflammation · OA · Metabolic
Tier 2 — Promising

What it is

A powerful natural anti-inflammatory that helps with joint pain and metabolic health. A 2025 analysis of 17 trials found all bioavailable turmeric forms significantly reduce knee arthritis pain. A 2024 review of 103 trials confirms it lowers inflammation markers and blood sugar. Must use a bioavailable form. Caution: mild anticoagulant effect — avoid at high doses if on warfarin or chemotherapy.

Efficacy
3/5
Safety
4/5
Research
4/5
Onset
2/5
Cost
3/5
Drug-int.
3/5

Dose

250–500 mg/day curcuminoids (phytosome, liposomal, or + piperine only); plain turmeric has negligible absorption

Time of day & tips

Take with a fatty meal to maximise absorption. Avoid taking on an empty stomach. Space 2 hours from blood-thinning medications. Avoid grapefruit juice.

Cycling

Safe for continuous daily use. No cycling needed. Long-term studies up to 12 months show good safety. Take breaks if digestive discomfort occurs.

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