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Corydalis yanhusuo

Pain · Traditional Chinese · Dopamine

Tier 3 — Trending

What it is

A Chinese medicinal rhizome (Corydalis yanhusuo) whose alkaloid fraction includes dehydrocorybulbine (DHCB), a dopamine D2 receptor antagonist with unusual analgesic activity against inflammatory, neuropathic, and injury-related pain in animal models. Traditional use for headache, menstrual cramps, and visceral pain spans over 2000 years. Human clinical evidence is emerging but limited; preliminary trials suggest benefit in chronic musculoskeletal and abdominal pain. Should not be combined with antipsychotics or dopaminergic drugs.

Efficacy

2/5

Safety

3/5

Research

2/5

Onset

3/5

Cost

3/5

Drug-int.

3/5

Dose

1–3 g dried rhizome or 500–1000 mg standardised extract 2–3 times daily

Time of day & tips

Avoid with antipsychotics, anti-parkinsonian drugs, and during pregnancy; may cause drowsiness — avoid driving initially; best evidence is for inflammatory/neuropathic rather than acute pain

Sensitive populations: This supplement's evidence base touches pregnancy, pediatric, or other sensitive populations. Confirm any change with your healthcare provider before use.

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