Collagen type II (undenatured, UC-II)
What it is
Distinct from hydrolysed collagen peptides. Works via oral tolerance — training the immune system to stop attacking joint cartilage. The canonical RCTs are Crowley 2009 (Int J Med Sci, 52 OA patients, UC-II 40 mg outperformed glucosamine+chondroitin) and Lugo 2016 (Nutr J, 191 knee-OA patients, UC-II vs placebo and G+C), both showing significant reductions in joint pain and stiffness. Must be taken on an empty stomach — food destroys the mechanism. Very safe with no notable side effects.
Dose
40 mg/day undenatured type II collagen (UC-II) on empty stomach; distinct mechanism from collagen peptides
Time of day & tips
Take on an empty stomach at least 30 min before food. Morning works well. Do not take alongside collagen peptides — they are different products with different mechanisms.
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